{"id":351,"date":"2021-05-27T16:31:00","date_gmt":"2021-05-27T20:31:00","guid":{"rendered":"https:\/\/www.reliasolve.com\/?p=351"},"modified":"2023-07-25T10:12:34","modified_gmt":"2023-07-25T14:12:34","slug":"university-lab-instrument-development","status":"publish","type":"post","link":"https:\/\/reliasolve.com\/index.php\/past-projects\/university-lab-instrument-development\/","title":{"rendered":"University Lab: Instrument Development"},"content":{"rendered":"\n<p>ReliaSolve worked with a university laboratory to help them complete the final stretch of their proof-of-concept deliverable for a contract, a combined digital and quantitative PCR device for measuring 8 samples at a time. This involved extending existing algorithms and working with project staff to integrate with their current code base. Ninety-one issues were resolved in 10 weeks (all-night work as required), including support for image analysis and control:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Improved robustness of image analysis based on instrument and data characteristics.<\/li>\n\n\n\n<li>Designed, implemented, and validated robust and accurate algorithm for estimating dPCR signals from a set of individual measurements that takes into account characteristics of observed data.<\/li>\n\n\n\n<li>Designed, implemented, and validated automatic tuning of parameters based on data from each experiment to increase robustness and accuracy of analysis.<\/li>\n\n\n\n<li>Designed, implemented, and validated reliable (X,Y) stage positioning and focus using brightfield and multiple fluorescence channels.<\/li>\n\n\n\n<li>Identified and addressed bottlenecks for data collection speed.<\/li>\n\n\n\n<li>Constructed modules for calibration of system hardware and optical characteristics.<\/li>\n\n\n\n<li>Constructed visualizations to support the assay development team and for final display to the customer.<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>ReliaSolve worked with a university laboratory to help them complete the final stretch of their proof-of-concept deliverable for a contract, a combined digital and quantitative PCR device for measuring 8 samples at a time. This involved extending existing algorithms and working with project staff to integrate with their current code base. Ninety-one issues were resolved [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-351","post","type-post","status-publish","format-standard","hentry","category-past-projects"],"_links":{"self":[{"href":"https:\/\/reliasolve.com\/index.php\/wp-json\/wp\/v2\/posts\/351","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/reliasolve.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/reliasolve.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/reliasolve.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/reliasolve.com\/index.php\/wp-json\/wp\/v2\/comments?post=351"}],"version-history":[{"count":5,"href":"https:\/\/reliasolve.com\/index.php\/wp-json\/wp\/v2\/posts\/351\/revisions"}],"predecessor-version":[{"id":559,"href":"https:\/\/reliasolve.com\/index.php\/wp-json\/wp\/v2\/posts\/351\/revisions\/559"}],"wp:attachment":[{"href":"https:\/\/reliasolve.com\/index.php\/wp-json\/wp\/v2\/media?parent=351"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/reliasolve.com\/index.php\/wp-json\/wp\/v2\/categories?post=351"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/reliasolve.com\/index.php\/wp-json\/wp\/v2\/tags?post=351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}